Thanks for the replies. To clarify, the Pro Tools software stops out putting signal. The individual tracks continue to play (as evidenced by the meters moving), but the master fader displays no audio output (nothing on the meter). So to answer your question there is no audio coming out of the headphone output, Analog Outputs 1-2, or the monitor outputs. Perhaps I'll try sending something to the analog 3-4 outputs and see what happens. I thought perhaps the CPU was being overloaded, so I set the buffer at 1024, and bypassed all my virtual instruments, but again, the problem persists. Sigh. :(