I picked up one of the UAD-1e cards that are $99 now.. and I must say, using it on a quad core in vista.. had no problems whatsoever, with REAPER's default settings.. used a bunch of plugs, loaded the card up to 90%, even used with reafir's creating more latency to be compensated.. everything really went smoothly (though not quite as smooth as the UAD-2).. strange! :)