There is no general best setting for anime, so a little more information would have been nice. Like how clean is the source, is it PAL or NTCS, is it interlaced, etc. Most anime could benefit from a smoother filter, but depending on how clean the source is there's good or bad filters. Also a simple search for anime or manga or cartoon (in this section and the avisynth section) would give you lots of nice posts with settings to read, without having to repeat all those settings here. Basically, whatever works for DivX5 anime encodes also works for XviD anime encodes.