buffering and multiple takes

Hello - I'm running very large projects with very low latency - 100-250 tracks in some cases - with no problems. However, I've noticed that when I accumulate multiple tracks, each with multiple takes (example would be recording a 4 piece band - maybe a dozen mics up - each allocated to a track - doing 8 takes or so). After a number of takes, Reaper will produce sputtering, intermittent audio when recording and/or playing back. The disk drive chatters furiously too. The time marker continues to move, but audio is messed up. However, if I move the time marker back to the beginning of the project, and let it play all the way through the project (with the sputtering audio), I'm able to record and play at will from there forward. If I close the project, I must re-do the play-thru process again to make the audio render correctly. This is obviously Reaper filling up buffers - but it only related to situations with (lots of) multiple takes. If I explode the takes into tracks and delete the original, multi-take track, the problem goes away. Does anyone know if there are buffering settings to fix this problem, or is it a bug related to multi-takes? Not the end of the world - but embarrassing when a client is recording their 6th take and the audio goes haywire.... thanks, jon

IIRC very large track counts may benefit from setting your disk read mode to "Asynchronous unbuffered" in 'Options->Preferences->Buffering->Advanced Disk I/O options'. Not sure how that relates to takes but trying won't harm.

will try when i get home...thx very much